Korean guideline for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer was previously developed under co-work with Korean College of Helicobacter and Upper Gastrointestinal Research and Korea Society of Gastroenterology at 2009. However, previous guideline lacked evidence-based developmental process although it was mode by sufficient review of previous related articles and consensus of expert opinions, and the revision of the guideline has not been implemented since 2009. Here, we formed a guideline development committee for drug-induced peptic ulcer under Korean College of Helicobacter and Upper Gastrointestinal Research at 2017, and developed 9 statements including 4 for NSAID, 3 for aspirin and other antiplatelet agent and 2 for anticoagulants through de novo process based on evidence based medicine such as literature search, meta-analysis and modified by Delphi method. The primary target of this guideline is adult patients taking long-term NSAID, aspirin or other antiplatelet agent and anticoagulant. The revised guideline was drafted and revised to reflect the opinions of external experts, and aimed to provide relevant clinicians optimal guidelines for management and prevention of drug-induced peptic ulcer and its complications.